The hunt for mitochondrially synthesized proteins
نویسندگان
چکیده
منابع مشابه
TET proteins: on the frenetic hunt for new cytosine modifications
Epigenetic genome marking and chromatin regulation are central to establishing tissue-specific gene expression programs, and hence to several biological processes. Until recently, the only known epigenetic mark on DNA in mammals was 5-methylcytosine, established and propagated by DNA methyltransferases and generally associated with gene repression. All of a sudden, a host of new actors-novel cy...
متن کاملActivity of mitochondrially synthesized reporter proteins is lower than that of imported proteins and is increased by lowering cAMP in glucose-grown Saccharomyces cerevisiae cells.
We selected for increased phenotypic expression of a synthetic cox2::arg8m-G66S reporter gene inserted into Saccharomyces cerevisiae mtDNA in place of COX2. Recessive mutations in ras2 and cyr1, as well as elevated dosage of PDE2, allowed cox2::arg8m-G66S to support Arg prototrophy. Each of these genetic alterations should decrease cellular cAMP levels. The resulting signal was transduced throu...
متن کاملNatural Ribosomally Synthesized Circular Proteins
Over recent years several examples of natural ribosomally synthesized circular proteins from a diverse range of organisms have been discovered. They are special molecules, whose precursors must be posttranslationally modified to join the N to C termini with a head-to-tail peptide bond. This feature appears to have a range of potential advantages over their linear counterparts, since they are le...
متن کاملComputational identification of human mitochondrial proteins based on homology to yeast mitochondrially targeted proteins
MOTIVATION Patients with defects of the mitochondrial respiratory chain due to mutations in nuclear genes are often undiagnosable due to the lack of information about the role of these genes. We therefore sought to produce a novel dataset of human nuclear-encoded mitochondrial proteins. RESULTS We have used the web-based computer program Mitoprot to predict which proteins in the Saccharomyces...
متن کاملThe hunt for SNARC
The SNARC effect specifically relates small magnitudes to the left hand side and larger magnitudes to the right hand side (e.g. Dehaene et al., 1990; Dehaene et al., 1993). It is certain that cultural characteristics define the SNARC effect: In western cultures small and large numbers are coded in a left-right direction while in Arabic countries magnitude information is coded from right to left...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1997
ISSN: 0961-8368
DOI: 10.1002/pro.5560060324